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www.55rfd.com_www.55rfd.com-【以丰富奖赏】

文章来源:SEO    发布时间:2019-04-25 07:44:40  【字号:      】

www.55rfd.com_www.55rfd.com-【以丰富奖赏】“MyuncleIvanwasaseverediabetespatient—heneededinjectionsthreetimesaday.Hewaswithoutinsulinformorethanamonth.EvenIwasnotaware,”Pablorecounts.“Whenhefinallyreceivedinsulin,hewasinbadcondition.Severalweekslater,hishealthdeclined,hehadrenalfailure,andhedied.”ThedroneteamrecentlyacknowledgedPablo’scontributions,andhispersonalloss,bygivingtheprojectanewnickname.Oncecalled“MajorTom”aftertheDavidBowiesong,it’snow“ProjectIvan.”“Idon’thavewordsenoughtoshowmygratitude,”Pablosays.“Thisisaboutsavinglives.”Ourcompanyiscommittedtodiscoveringsmart,sustainablewaystoexpandaccesstohealthcare,especiallyinareaswithlimitedinfrastructureandresources.Giventhesignificanceofthischallenge,itisonlybyworkinginpartnershipwithothers—governments,donors,patientorganizations,healthcareprofessionals,NGOs,academicinstitutions,multilateralorganizationsandtheprivatesector—thatwecanwemakethestrongestcontribution.TheMSDFellowshipforGlobalHealthisbuiltonthenotionofpartneringtostrengthenthecapacityandreachofnonprofitorganizationswhich,inturn,willultimatelysolvesomeoftheworld’sgreatesthealthcarechallenges.CarolineFox,M.D.ispassionateaboutgenetics.Inmedicalschool,shestudiedtheeffectsoftheenvironmentondiabetesandobesityonatribeofNativeAmericans(certainpopulationsworldwidehaveagreaterpropensitytowardsdiabetes;thistribewasonesuchgroup).Herresearchlefthermotivatedtolearnmoreabouthowgeneticsplaysaroleinmetabolicdiseases.Thatwasmystart,shenotes.Sincethen,almostallofmyresearchhasbeenfocusedonuncoveringthegeneticfoundationsofthesetypesofdiseases.ChangingPerceptionsPriortojoiningMSDResearchLaboratoriesinBoston,CarolineworkedattheNationalInstitutesofHealth.There,sheledalabthatstudiedmetabolicriskfactorsforcardiovasculardiseaseaspartofthe,apioneeringlong-termpopulationstudyofcardiovasculardisease.But,shenotes,theshifttoMSDwasarelativelyeasyone.IwasimpressedbyMSDseffortstoleveragehumangeneticstodrivedrugdiscovery,shesays.Forme,itwastheperfectnextstepfromtheworkthatIhadbeendoinginacademia.Genetics:TheNewFrontierWe'relucky—CarolinespassionforgeneticsisagreatfitforMSD.Inourlabsandacrosstheindustry,weareseeinganincreaseduseofhumangeneticstohelpdeterminewhetherpatientswillrespondtoacertaindrugornot,ShepointstoMSD'sactiveresearchcollaborationswithscientistsaroundtheworldaimedatadvancingthisfieldofscience.Iamveryenthusiasticaboutwhereourresearchmaylead.

Dr.Chenghasbeentreatingheadandneckcancerpatientsformanyyears.Thisishispersonalperspective.Ihavetreatedpatientswithheadandneckcancersformanyyears,soIhaveseen,upclose,thedifficultexperienceoflivingwithheadandneckcancer.Cancerisatryingsituationforallpatientsandtheirlovedones,butheadandneckpatientsfacecancerinauniqueanddifficultway,withtheirdiseaseandtumorsoftenvisibletothepublic.Ihavebeeninvolvedinresearchforyearsaspartofscientists'decades-longendeavortobringforwardmeaningfuladvancesforpatientsdiagnosedwiththispotentiallyaggressivedisease.Untilrecently,suchadvanceswerehardtocomebyandmypatientsandIstruggledwiththelimitedtreatmentoptionsavailable.Butwhilethereisasignificantneedfornewtreatmentoptions,thegoodnewsisthattherehavebeensomeimprovementsinsurvivalratesovertheyearsandweareseeinganewandencouragingfutureahead.Wehavebeguntoleverageourunderstandingofbiologytodevelopmoreprecisetherapies.AtMSD,wearefocusedonimmuno-oncologyresearch,whichstudiestheroleoftheimmunesystemindetectingandfightingcancer.Wearestudyingthepotentialofthisapproach,whichaimstoharnessandrestorethebodysabilitytodetectandfightcancercells,inanumberofcancers,includingheadandneckcancer.Immuno-oncologyhasalreadysignificantlychangedthewaycertaincancersaretreated,includingmelanomaandlungcancer,aswellasinthetreatmentofheadandneckcancer.Changeiscomingtotheheadandneckcancerlandscape–anditisthrillingtobeapartofit.TobeabletoseehowourresearchandeffortsatMSDarehavingadirectimpactonhowphysiciansapproachthetreatmentoftheirpatientsandwhatpatientsmayexpectfromtheirtreatmentiswhatmotivatesustoworkharder.Jameslikeslogicpuzzles.Andwordproblems.Luckily,hegetstoapplytheseinterestsinhisworkeveryday.Jamesisacomputationalchemist–heworkswithMSD’schemistryteams,applyingpredictivemodellingtoidentifywaystodesigndrugsandanalyzedatatohelpourscientistsprioritizethenextcompoundstomakeandtest.Althoughthesearecomplexproblemsandcomplexquestionsthatwe’retryingtosolve,wetakelogicalsteps,explainsJames.Foreveryquestion,there’sreallyananswer,yousometimesjusthavetospendalittlebitmoretimethinkingaboutit,andtakeastepbackandlookatwhat’sactuallyinfrontofyou.Bettermolecules,fasterInourgroup’sroleindrugdiscovery,wehavethismantraof‘bettermolecules,faster,saysJames.Ifachemisthas100compoundsthatshe’sthinkingaboutmaking,computationally,wecanhelpprioritizewhichonestostartwithbasedonrationaldrugdesign.Jamesenjoysbeingpartofateamworkingtoachieveasingulargoal:tocreatemedicinesthatwillhelpthepeoplewhoneedthem.And,hebelievesthatcollaborationisveryimportantforresearchanddevelopment:Youcan'tdoaprojectonyourown;youneedotherstoassistandhelp,notjustbycontributingintheirindividualrole,butalsowiththeirthinking.Jamesandhiscolleagueshavealotofexperiencewithperseveranceanddetermination,too.Ourteamsofscientistsdesign,developandscreenthousandsofcompoundsandantibodiestoultimatelyadvanceonlyafewofthemostpromisingleadcandidatesintoclinicaltesting.Moleculardesignanddevelopmentisaniterativeprocess.Youhavetostickwithit.It'scontinuouslymakingmodificationsandadaptingandevolving,eventuallygettingdowntheroadorthepipelinetomakeadrug…that'swhat'sexcitingaboutit.It’sallaboutthepatientsEveryday,IcometoworkknowingthatI’mworkingtomakeadrug.And,Idon'tknowiftodayI’mgoingtoopenupanemailwithresultssaying,‘we'veaccomplishedthisor‘weneedtochangethat.’Butregardlessofwhatthoseresultsare,it'sgoingtobeprogresstogettothatendpoint.”Jameslikeslogicpuzzles.Andwordproblems.Luckily,hegetstoapplytheseinterestsinhisworkeveryday.Jamesisacomputationalchemist–heworkswithMSD’schemistryteams,applyingpredictivemodellingtoidentifywaystodesigndrugsandanalyzedatatohelpourscientistsprioritizethenextcompoundstomakeandtest.Althoughthesearecomplexproblemsandcomplexquestionsthatwe’retryingtosolve,wetakelogicalsteps,explainsJames.Foreveryquestion,there’sreallyananswer,yousometimesjusthavetospendalittlebitmoretimethinkingaboutit,andtakeastepbackandlookatwhat’sactuallyinfrontofyou.Bettermolecules,fasterInourgroup’sroleindrugdiscovery,wehavethismantraof‘bettermolecules,faster,saysJames.Ifachemisthas100compoundsthatshe’sthinkingaboutmaking,computationally,wecanhelpprioritizewhichonestostartwithbasedonrationaldrugdesign.Jamesenjoysbeingpartofateamworkingtoachieveasingulargoal:tocreatemedicinesthatwillhelpthepeoplewhoneedthem.And,hebelievesthatcollaborationisveryimportantforresearchanddevelopment:Youcan'tdoaprojectonyourown;youneedotherstoassistandhelp,notjustbycontributingintheirindividualrole,butalsowiththeirthinking.Jamesandhiscolleagueshavealotofexperiencewithperseveranceanddetermination,too.Ourteamsofscientistsdesign,developandscreenthousandsofcompoundsandantibodiestoultimatelyadvanceonlyafewofthemostpromisingleadcandidatesintoclinicaltesting.Moleculardesignanddevelopmentisaniterativeprocess.Youhavetostickwithit.It'scontinuouslymakingmodificationsandadaptingandevolving,eventuallygettingdowntheroadorthepipelinetomakeadrug…that'swhat'sexcitingaboutit.It’sallaboutthepatientsEveryday,IcometoworkknowingthatI’mworkingtomakeadrug.And,Idon'tknowiftodayI’mgoingtoopenupanemailwithresultssaying,‘we'veaccomplishedthisor‘weneedtochangethat.’Butregardlessofwhatthoseresultsare,it'sgoingtobeprogresstogettothatendpoint.”Ourcompanyiscommittedtodiscoveringsmart,sustainablewaystoexpandaccesstohealthcare,especiallyinareaswithlimitedinfrastructureandresources.Giventhesignificanceofthischallenge,itisonlybyworkinginpartnershipwithothers—governments,donors,patientorganizations,healthcareprofessionals,NGOs,academicinstitutions,multilateralorganizationsandtheprivatesector—thatwecanwemakethestrongestcontribution.TheMSDFellowshipforGlobalHealthisbuiltonthenotionofpartneringtostrengthenthecapacityandreachofnonprofitorganizationswhich,inturn,willultimatelysolvesomeoftheworld’sgreatesthealthcarechallenges.

Toexpressourappreciation,MSDbegan#DearCancerHeroes–asocialmediacampaigntorecognizetheirfortitudeandcontributionstothefield.It’sasmallgesturetoshowourgratitude.Wewanttoletclinicaltrialparticipantsknowtheyarenotaloneandthereisawholecommunityofpeoplecheeringthemon.Anyonecanjointhemovementbywritingamessagetocancerclinicaltrialparticipantsonastickynoteandsharingitonsocialmediausing#DearCancerHeroes.Cancerresearchhascomealongwayandstillhasalongwaytogo.However,wewouldn’thavegottentowherewearetodaywithouttheseheroes.Dr.Chenghasbeentreatingheadandneckcancerpatientsformanyyears.Thisishispersonalperspective.Ihavetreatedpatientswithheadandneckcancersformanyyears,soIhaveseen,upclose,thedifficultexperienceoflivingwithheadandneckcancer.Cancerisatryingsituationforallpatientsandtheirlovedones,butheadandneckpatientsfacecancerinauniqueanddifficultway,withtheirdiseaseandtumorsoftenvisibletothepublic.Ihavebeeninvolvedinresearchforyearsaspartofscientists'decades-longendeavortobringforwardmeaningfuladvancesforpatientsdiagnosedwiththispotentiallyaggressivedisease.Untilrecently,suchadvanceswerehardtocomebyandmypatientsandIstruggledwiththelimitedtreatmentoptionsavailable.Butwhilethereisasignificantneedfornewtreatmentoptions,thegoodnewsisthattherehavebeensomeimprovementsinsurvivalratesovertheyearsandweareseeinganewandencouragingfutureahead.Wehavebeguntoleverageourunderstandingofbiologytodevelopmoreprecisetherapies.AtMSD,wearefocusedonimmuno-oncologyresearch,whichstudiestheroleoftheimmunesystemindetectingandfightingcancer.Wearestudyingthepotentialofthisapproach,whichaimstoharnessandrestorethebodysabilitytodetectandfightcancercells,inanumberofcancers,includingheadandneckcancer.Immuno-oncologyhasalreadysignificantlychangedthewaycertaincancersaretreated,includingmelanomaandlungcancer,aswellasinthetreatmentofheadandneckcancer.Changeiscomingtotheheadandneckcancerlandscape–anditisthrillingtobeapartofit.TobeabletoseehowourresearchandeffortsatMSDarehavingadirectimpactonhowphysiciansapproachthetreatmentoftheirpatientsandwhatpatientsmayexpectfromtheirtreatmentiswhatmotivatesustoworkharder.“MyuncleIvanwasaseverediabetespatient—heneededinjectionsthreetimesaday.Hewaswithoutinsulinformorethanamonth.EvenIwasnotaware,”Pablorecounts.“Whenhefinallyreceivedinsulin,hewasinbadcondition.Severalweekslater,hishealthdeclined,hehadrenalfailure,andhedied.”ThedroneteamrecentlyacknowledgedPablo’scontributions,andhispersonalloss,bygivingtheprojectanewnickname.Oncecalled“MajorTom”aftertheDavidBowiesong,it’snow“ProjectIvan.”“Idon’thavewordsenoughtoshowmygratitude,”Pablosays.“Thisisaboutsavinglives.”

Historically,oncologypracticeandclinicaltrialdesignprimarilyfocusedonwherethetumorfirstemerged,suchascolonorrectum,lung,breast,andendometrium.Thisapproachfollowsthelogicofthescalpel:pinpointingthelocationofthetumorfirstenabledsurgicalplans.Morerecently,therehavebeensignificantadvancesinourunderstandingoftheroleofcancerbiomarkersinmolecularandcellularmechanismsthatcandrivetumorgrowth.Biomarkersarebiologicalmolecules(typicallycomprisedofDNA,RNAorprotein)foundintissuesorbloodthatcanserveasasigntobetterunderstandaconditionordisease.Sometimes,thesamebiomarkerisfoundacrossmanydifferenttypesofcancer,regardlessofwherethetumorfirstdeveloped.Withinaspecifictumorlocation,thesebiomarkerscansometimesdifferentiatewhetherthetumorislikelytorespondtoagiventreatment.Assuch,thesebiomarkershavebeenusedtohelpinformclinicalresearch,acceleratingtheprocessofgettingtargetedmedicinestopatientswhereseparatetrialswouldtakeyearstoconduct.Importantly,insomecases,thesefeaturescanbeassessedusinglaboratoryteststhathavelongbeenavailable.Whereatestiseithernotavailable,orforresearchuseonly,thetestmanufacturerpartnerswiththedrugmanufacturertoadvancetogetherintoregulatoryapprovalbygovernmentagencies(suchastheFDA)acompaniondiagnosticassaytoensuresafeandeffectiveuseofthedruginpatientslikelytorespond.Thegoalistouseadeeperunderstandingofthetumorbiologyandassociatedbiomarkerstotackletumorresearchmoreprecisely;goingbeyondsimplywhereatumorarose.Instead,wearelearninghowtoattackacancerbasedonitsbiologyatthecellularlevel.AtMSD,effortsareunderwaytobetterunderstandmicrosatelliteinstability(MSI)andmismatchrepairdeficiency(dMMR).Thesebiomarkersarepresentacrosstumortypes,regardlessoftheoriginallocationofthecancer.ThepresenceofhighlevelsofMSI(MSI-H)ordMMRsignifiesanunderlyingprobleminacell'sabilitytofixerrorsthatoccurwhenDNAreplicates.TumorcellsdeterminedtohaveMSI-HordMMRharborhundredstothousandsofmutations.Theultimateproofofoureffortswillmanifestasanewgenerationofcancermedicines:thosethatfollowthelogicofbiology,notthelogicofthescalpel.CarolineFox,M.D.ispassionateaboutgenetics.Inmedicalschool,shestudiedtheeffectsoftheenvironmentondiabetesandobesityonatribeofNativeAmericans(certainpopulationsworldwidehaveagreaterpropensitytowardsdiabetes;thistribewasonesuchgroup).Herresearchlefthermotivatedtolearnmoreabouthowgeneticsplaysaroleinmetabolicdiseases.Thatwasmystart,shenotes.Sincethen,almostallofmyresearchhasbeenfocusedonuncoveringthegeneticfoundationsofthesetypesofdiseases.ChangingPerceptionsPriortojoiningMSDResearchLaboratoriesinBoston,CarolineworkedattheNationalInstitutesofHealth.There,sheledalabthatstudiedmetabolicriskfactorsforcardiovasculardiseaseaspartofthe,apioneeringlong-termpopulationstudyofcardiovasculardisease.But,shenotes,theshifttoMSDwasarelativelyeasyone.IwasimpressedbyMSDseffortstoleveragehumangeneticstodrivedrugdiscovery,shesays.Forme,itwastheperfectnextstepfromtheworkthatIhadbeendoinginacademia.Genetics:TheNewFrontierWe'relucky—CarolinespassionforgeneticsisagreatfitforMSD.Inourlabsandacrosstheindustry,weareseeinganincreaseduseofhumangeneticstohelpdeterminewhetherpatientswillrespondtoacertaindrugornot,ShepointstoMSD'sactiveresearchcollaborationswithscientistsaroundtheworldaimedatadvancingthisfieldofscience.Iamveryenthusiasticaboutwhereourresearchmaylead.Ourcompanyiscommittedtodiscoveringsmart,sustainablewaystoexpandaccesstohealthcare,especiallyinareaswithlimitedinfrastructureandresources.Giventhesignificanceofthischallenge,itisonlybyworkinginpartnershipwithothers—governments,donors,patientorganizations,healthcareprofessionals,NGOs,academicinstitutions,multilateralorganizationsandtheprivatesector—thatwecanwemakethestrongestcontribution.TheMSDFellowshipforGlobalHealthisbuiltonthenotionofpartneringtostrengthenthecapacityandreachofnonprofitorganizationswhich,inturn,willultimatelysolvesomeoftheworld’sgreatesthealthcarechallenges.

陈伟俊这次调研不寻常 六个字打开温州开放之门




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